|1626-2||INCIDENCE OF NOROVIRUS, ASTROVIRUS AND ADENOVIRUS INFECTION AMONG
CHILDREN WITH ACUTE GASTROENTERITIS IN PORTO VELHO-RONDONIA, BRAZIL
|Autores:||Maria Sandra Costa Amaral (FIOCRUZ RO - Fundação Oswaldo Cruz Rondônia / CEPEM - CENTRO DE PESQUISA EM MEDICINA TROPICAL) ; Grecy Kelli Estecam Sales (FIOCRUZ RO - Fundação Oswaldo Cruz Rondônia / CEPEM - CENTRO DE PESQUISA EM MEDICINA TROPICAL) ; Marilene Penati (HICD - Hospital Infantil Cosme e Damião) ; Najla Benevides Matos (FIOCRUZ RO - Fundação Oswaldo Cruz Rondônia / CEPEM - CENTRO DE PESQUISA EM MEDICINA TROPICAL) |
Acute gastroenteritis is a common disorder in young children. It is associated with dehydration, a leading cause of hospital admissions in industrialized nations and a major source of mortality in developing countries. Enteric viruses have been identified as the most significant etiological agents of the disease, with four categories of viruses being considered clinically relevant: Group A rotavirus, norovirus, adenovirus, and astrovirus. With the exception of Rotavirus, whose importance has been well established in the medical community due to its high prevalence and worldwide impact, little is known about the epidemiology of the other three groups of viruses. This study aimed to determine the incidence of infection the norovirus, the adenovirus and the astrovirus in children 0-6 years of age admitted with acute gastroenteritis to a public children's hospital in the city of Porto Velho, Rondonia. Between the periods of February 2010 and February 2012 a total of 591 stool samples from children were analyzed for the presence of adenovirus type F 40/41, using the enzyme immunoassay (ELISA) and confirmed by PCR methodology. Detection of norovirus and astrovirus was accomplished by RT-PCR using primers specific for each viral type. There were 98 cases (98/591) of enterovirus infection detected, with infection rates of 8.9% (53/591), 5.2% (31/591) and 2.3% (14/591) for norovirus, astrovirus, and the adenovirus respectivelly. 9.1% of the children were co-infected with norovirus and astrovirus. There was a higher incidence of infection in children ages 0-24 months. All children had typical symptoms associated with enteroviral infection, including diarrhea, vomiting and fever. Bloody stool was found in 16.9% (6/31) of the norovirus infected children, in 19.3% (6/31) of astrovirus infecion and in 21.4% (3/14) of adenovirus infection. Viral infection was detected mainly in the months of February through May, the period corresponding to the rainy season in Porto Velho. A higher incidence of norovirus was detected in the periods of March and April of 2010 with 20.4% (20/98) of cases, with lower rates in the subsequent year. The data presented here may contribute to a better understanding of the role of enteroviral infection in the pediatrics population of Porto Velho, Rondonia and may be important in the strategic planning of control of the disease in this region.
Palavras-chave: Enteric viruses, CHILDREN, ACUTE GASTROENTERITIS