|1170-1||Acremonium strictum infection in hematopoietic stem cell transplanted recipient. Case report|
|Autores:||Milton Camplesi Junior (UNIP - Universidade Paulista) ; Adriano Morais Arantes (HAJ - Hospital Araujo Jorge) ; Hildene Meneses Silva (UFG - Universidade Federal de Goiás) ; Carolina Rodrigues Costa (UFG - Universidade Federal de Goiás) ; Fernanda Almeida Andrade (UFG - Universidade Federal de Goiás) ; Maysa Paula da Costa (UFG - Universidade Federal de Goiás) ; Maria do Rosário Rodrigues Silva (UFG - Universidade Federal de Goiás) |
Introduction: Invasive infections caused by opportunistic yeasts and molds are a significant cause of morbidity and mortality in severely immunocompromised hosts. A case of Acremonium strictum fungemia with proven involvement of the lungs in an allogeneic hematopoietic stem cell transplant is reported. Material and Methods: A high-resolution computed tomography scan of the lungs and cultures on Sabouraud dextrose and brain-heart-infusion from the peripheral catheter and blood were performed for diagnosis of fungal infection. Susceptibility testing of the clinical isolate was performed in duplicate using a broth microdilution test following the Clinical and Laboratory Standards Institute (CLSI) guidelines. Results and discussion: The computed tomography scan sowed nodules in both lungs, and multiple cultures of blood demonstrated narrow septate hyphae, cylindrical conidia and solitary tapering phialides and microconidia that remained grouped in slimy heads which were identified as A. strictum. Amphotericin B, fluconazole and itraconazole were found to be inactive in vitro against the isolate; however it was found to be sensitive to voriconazole. Conclusions: One year later, the patient was free of symptoms and her blood culture was negative for fungi. Then, voriconazole appears to be effective in treatment for life-threatening A. strictum. infections.
Palavras-chave: Acremonium strictum, hematopoietic stem cell, voriconazole