XI International Meeting on Paracoccidioidomycosis

XI International Meeting on Paracoccidioidomycosis

Resume:172-1

Investigação

172-1	The clinical and epidemiological features of Paracoccidioidomycosis in the Southeast of Brazil: report of a cohort of 1 000 patients.
Authors:	Roberto Martinez (FMRP-USP - Fac Medicina de Ribeirão Preto-USP)

Abstract

Introduction - The information about the epidemiology and clinical features of paracoccidioidomycosis mainly results from the observation of large case series. This study reports original data about 1 000 cases from the Ribeirão Preto region, Northeast of the State of São Paulo, Brazil.਀䴀攀琀栀漀搀漀氀漀最礀 ⴀ 吀栀椀猀椀猀愀爀攀琀爀漀猀瀀攀挀琀椀瘀攀猀琀甀搀礀漀昀瀀愀琀椀攀渀琀猀搀椀愀最渀漀猀攀搀愀渀搀琀爀攀愀琀攀搀昀漀爀瀀愀爀愀挀漀挀挀椀搀椀漀椀搀漀洀礀挀漀猀椀猀戀攀琀眀攀攀渀㄀㤀㜀　愀渀搀㄀㤀㤀㤀愀琀琀栀攀唀渀椀瘀攀爀猀椀琀礀䠀漀猀瀀椀琀愀氀Ⰰ 䘀䴀刀倀ⴀ唀匀倀⸀ 吀栀攀椀渀挀椀搀攀渀挀攀漀昀琀栀攀搀椀猀攀愀猀攀眀愀猀攀猀琀椀洀愀琀攀搀椀渀爀攀氀愀琀椀漀渀琀漀琀栀攀瀀漀瀀甀氀愀琀椀漀渀漀昀瘀愀爀椀漀甀猀洀甀渀椀挀椀瀀愀氀椀琀椀攀猀椀渀琀栀攀搀椀猀琀爀椀挀琀漀昀刀椀戀攀椀爀漀倀爀攀琀漀⸀ Results - Between 1980 and 1999 the mean incidence of paracoccidioidomycosis was 2.70 cases/100,000 inhabitants/year. The patients ranged in age from 3 to 85 years old (mean = 40.8) and the male:female ratio was 6:1. About 94% of the patients had resided or worked in a rural area. Excessive intake of distilled drinks and smoking habit were reported by 37% and 65% of the patients, respectively. Other infectious and parasitic diseases, concomitant or not with paracoccidioidomycosis, were Chagas’ disease, tuberculosis, HIV/AIDS, leishmaniasis, leprosy, and strongyloidiasis. The acute/subacute form of paracoccidioidomycosis was detected in 25% of the cases, predominating among patients aged 3 to 30 years old , among women, and among Blacks. The chronic form was the most common presentation in patients older than 30 years, in men and in patients with a lighter skin. Sulfamide or azole drugs were used to treat most of the patients, 85% of whom were cured or experienced clinical improvement. Recurrence and death attributed to paracoccidioidomycosis were observed in 10% and 8% of cases, respectively.਀䌀漀渀挀氀甀猀椀漀渀ⴀ 䔀瘀椀搀攀渀挀攀漀昀栀礀瀀攀爀攀渀搀攀洀椀挀椀琀礀漀昀瀀愀爀愀挀漀挀挀椀搀椀漀椀搀漀洀礀挀漀猀椀猀眀愀猀搀攀琀攀挀琀攀搀椀渀琀栀攀最攀漀最爀愀瀀栀椀挀愀爀攀愀漀昀刀椀戀攀椀爀漀倀爀攀琀漀Ⰰ 匀倀Ⰰ 䈀爀愀稀椀氀⸀ 吀栀攀爀攀眀愀猀愀栀椀最栀瀀爀漀瀀漀爀琀椀漀渀漀昀挀愀猀攀猀眀椀琀栀琀栀攀愀挀甀琀攀⼀猀甀戀愀挀甀琀攀昀漀爀洀Ⰰ 眀椀琀栀愀渀愀猀猀漀挀椀愀琀椀漀渀攀砀椀猀琀椀渀最戀攀琀眀攀攀渀挀氀椀渀椀挀愀氀昀漀爀洀愀渀搀愀最攀Ⰰ 最攀渀搀攀爀愀渀搀攀琀栀渀椀挀最爀漀甀瀀⸀

Keyword: Paracoccidiomycosis, Epidemiology, Incidence, Sulfamide drugs, Azole drugs

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