XI International Meeting on Paracoccidioidomycosis

XI International Meeting on Paracoccidioidomycosis

Resume:152-3

Poster (Painel)

152-3

ASSOCIATION BETWEEN PARACOCCIDIOIDOMYCOSIS AND TUBERCULOSIS. WHEN TO SUSPECT?

Authors:

Aline Barbosa-silva (UFMS - Universidade Federal de Mato Grosso do Sul) ; Sandra Maria do Valle Leone Oliveira (UFMS - Universidade Federal de Mato Grosso do Sul) ; Ana Paula da Costa-marques (UFMS - Universidade Federal de Mato Grosso do Sul) ; Lilian Cristina Ferreira Andries (UFMS - Universidade Federal de Mato Grosso do Sul) ; Anamaria Mello Miranda Paniago (UFMS - Universidade Federal de Mato Grosso do Sul)

Abstract

Introduction. The paracoccidioidomycosis (PCM) is the most important endemic mycosis in Latin America, and the association between PCM and tuberculosis (TB) is not rare. The PCM and TB can happen due to a recent infection or to reactivation from a quiescent focus. The endogenous cellular immune deficiency appears to be primarily responsible for the development of both diseases. Patients may have PCM and TB simultaneously or sequentially. One can facilitate the reactivation of the other due to weakened immune system. The co morbidity diagnosis is difficult due to the similarity between their clinical and radiographic presentations. Objective. To analyze the differences of the clinical, epidemiological and laboratory characteristics of the PCM with and without TB. Patients/Methods. The study included patients with definitive diagnosis of PCM who were attended at a University Hospital from January 1998 until December 2008. These patients are submitted, by routine, to laboratory investigation for tuberculosis. The cases (164 patients) were divided into two groups: patients with PCM who had a confirmed diagnosis of tuberculosis (14) and patients with PCM without tuberculosis (150). The data were analyzed and compared using the program Epi Info version 3.4.3. Results. The prevalence of TB was 8.5%. PCM patients with tuberculosis had more fever, asthenia, hypotension, cough, lymphadenopathy, pulmonary lesions, lower levels of hemoglobin and serum albumin, and higher levels of erythrocyte sedimentation rate (p <0.05). Conclusion. The possibility of TB existence in PCM patients should always be considered, especially in those patients with PCM who have these characteristics. Financial support. Department of Science and Technology of Health Ministry of Brazil (DECIT-MS).

Keyword: Paracoccidiodomycosis, Tuberculosis, Co morbidity

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