XI International Meeting on Paracoccidioidomycosis

XI International Meeting on Paracoccidioidomycosis

Resume:151-1

Poster (Painel)

151-1

Analysis of the Skin Sensitization to Paracoccidioides brasiliensisi in Residents of Rural Areas of Alfenas, MG, Brazil

Authors:

Luiz Cosme Cotta Malaquias (UNIFAL-MG - Universidade Federal de Alfenas) ; Evandro Monteiro de Sá Magalhães (UNIFAL-MG - Universidade Federal de Alfenas) ; Carla de Fátima Ribeiro (UNIFAL-MG - Universidade Federal de Alfenas) ; Carla Silva Dâmaso (UNIFAL-MG - Universidade Federal de Alfenas) ; Maria Rita Rodrigues (UNIFAL-MG - Universidade Federal de Alfenas) ; Sônia Maria de Souza Lima Paes (SMS - Secretaria Municipal de Saúde de Alfenas) ; Zoilo Pires de Camargo (UNIFESP - Universidade Federal de São Paulo) ; Luiz Felipe Leomil Coelho (UNIFAL-MG - Universidade Federal de Alfenas) ; Roberta Ribeiro Silva (UNIFAL-MG - Universidade Federal de Alfenas) ; Tânia Regina Grão Velloso (UFES - Universidade Federal do Espírito Santo)

Abstract

Paracoccidioidomycosis is an endemic systemic mycosis caused by the thermal dimorphic fungus Paracoccidioides brasiliensis. Occurs more frequently in adult male inhabitants or workers from rural areas. Its primary route of entry is the respiratory tract. The infection control depends on the cellular immune response and may result in the formation of compact granulomas, which lets the control of the fungus replication. In general, the diagnosis is made by serologic testing of double immunodiffusion, but can also be done by ELISA. Other tests, such as intradermal skin test, contribute in the assessment of prevalence, as identification of asymptomatic or not, providing guidance and forward these to control or treatment. This work was carried out an epidemiological study of Paracoccidioidomycosis in rural area of Alfenas, Minas Gerais, Brazil. For this, we used the intradermal skin test with exoantigen paracoccidioidin. Survey participants were assessed after 48 hours to read the diameter of induration in the skin. Of the 542 skin tests, 236 were positive corresponding to 43.54% of prevalence. Regarding gender, 61.02% were male and 38.98% female. In relation to the profession, most worked or work in rural areas (53.50%), which show the greatest exposure of these individuals to Paracoccidioides brasiliensis. Most residents had no smoking behaviour and this variable was not significant for this test. In the present study we found a high prevalence of residents living in rural areas tested positive for the intradermal test (43.54%). This test proved to be an important way to identify whether or not an individual has been sensitized by the antigen and thus make a case for monitoring the disease manifests itself in the future, be treated early. Moreover, with the test can confirm the endemicity of paracoccidioidomycosis in rural localities of Alfenas and it is important to alert the population of this country, the necessity of testing as a way to quickly diagnose the disease before the onset of symptoms and to perform adequate treatment. Financial support: Unifal-MG

Keyword: Paracoccidioidomycosis, Epidemiology, Intradermal skin tests

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