Abstract

Paracoccidioides brasiliensis, the causative agent of paracoccidioidomycosis (PCM) was first reported by Adolpho Lutz in São Paulo, 1908. PCM is one of the most frequent systemic mycoses reported in South America, particularly Brazil, Colombia and Venezuela. Until the beginning of the 6th decade of the past century, research on PCM was mainly restricted to clinical aspects of the disease, although morphological observations started from the very beginning, Lutz himself describing the dimorphic character of the fungus. From the late 1960s onwards, early microscopic research on the biology of P. brasiliensis scaled up to electron microscopic observations on its ultrastructure, followed by chemical studies on cell wall composition, which provided initial evidence of chemical changes involved in both the dimorphic process and the pathogenicity of Paracoccidioides. Immunological aspects of the disease have also been studied at large, providing a wealth of information that has been instrumental in clinics. These studies, however, will not be covered in this conference. ਀吀栀攀 搀攀瘀攀氀漀瀀洀攀渀琀 漀昀 洀漀氀攀挀甀氀愀爀 琀漀漀氀猀 昀漀爀 琀栀攀 猀琀甀搀礀 漀昀 戀椀漀氀漀最椀挀愀氀 猀礀猀琀攀洀猀 爀攀猀甀氀琀攀搀 椀渀 琀栀攀 椀渀挀漀爀瀀漀爀愀琀椀漀渀 漀昀 琀栀攀洀 琀漀 昀甀爀琀栀攀爀 猀琀甀搀椀攀猀 漀渀 㰀椀㸀倀⸀ 戀爀愀猀椀氀椀攀渀猀椀猀㰀⼀椀㸀Ⰰ 昀爀漀洀 琀栀攀 ㄀㤀㜀　猀 漀渀眀愀爀搀猀⸀ 圀椀琀栀 琀栀攀洀Ⰰ 瀀栀攀渀漀洀攀渀愀 猀甀挀栀 愀猀 搀椀洀漀爀瀀栀椀猀洀Ⰰ 瘀椀爀甀氀攀渀挀攀 昀愀挀琀漀爀猀Ⰰ 椀洀洀甀渀漀氀漀最礀 漀昀 琀栀攀 搀椀猀攀愀猀攀Ⰰ 搀攀瘀攀氀漀瀀洀攀渀琀 漀昀 瀀漀琀攀渀琀椀愀氀 瘀愀挀挀椀渀攀猀Ⰰ 愀渀搀 洀愀渀礀 漀琀栀攀爀猀 栀愀瘀攀 爀攀愀挀栀攀搀 愀 猀琀愀最攀 漀昀 猀漀瀀栀椀猀琀椀挀愀琀椀漀渀 栀愀爀搀氀礀 昀漀爀攀猀攀攀渀 戀礀 攀愀爀氀礀 爀攀猀攀愀爀挀栀攀爀猀 椀渀 琀栀攀 昀椀攀氀搀⸀ 䄀搀搀椀琀椀漀渀愀氀氀礀Ⰰ 琀栀攀 搀椀猀挀漀瘀攀爀礀 漀昀 洀漀氀攀挀甀氀愀爀 猀瀀攀挀椀攀猀 眀椀琀栀椀渀 琀栀攀 最攀渀甀猀 㰀椀㸀倀愀爀愀挀漀挀挀椀搀椀漀椀搀攀猀㰀⼀椀㸀 ⠀琀栀攀 挀爀礀瀀琀椀挀 猀瀀攀挀椀攀猀 匀㄀Ⰰ 倀匀㈀ 愀渀搀 倀匀㌀Ⰰ 愀渀搀 㰀椀㸀倀愀爀愀挀漀挀挀椀搀椀漀椀搀攀猀 氀甀琀稀椀椀㰀⼀椀㸀⤀ 洀愀礀 栀攀氀瀀 椀渀 琀栀攀 甀渀搀攀爀猀琀愀渀搀椀渀最 漀昀 攀瀀椀搀攀洀椀漀氀漀最椀挀愀氀Ⰰ 椀洀洀甀渀漀氀漀最椀挀愀氀Ⰰ 愀渀搀 挀氀椀渀椀挀愀氀 昀攀愀琀甀爀攀猀 琀栀愀琀 栀愀瘀攀 爀攀洀愀椀渀攀搀 漀戀猀挀甀爀攀 琀漀 琀栀椀猀 搀愀礀⸀ 䘀甀爀琀栀攀爀洀漀爀攀Ⰰ 愀 挀漀渀琀椀渀攀渀琀愀氀 攀昀昀漀爀琀 挀愀爀爀椀攀搀 漀甀琀 戀礀 琀栀攀 䈀爀漀愀搀 䤀渀猀琀椀琀甀琀攀 ⠀䴀䤀吀Ⰰ 䈀漀猀琀漀渀Ⰰ 䴀愀猀猀⸀⤀ 琀漀最攀琀栀攀爀 眀椀琀栀 愀氀氀 洀愀椀渀 䰀愀琀椀渀 䄀洀攀爀椀挀愀渀 氀愀戀漀爀愀琀漀爀椀攀猀 椀渀瘀漀氀瘀攀搀 椀渀 洀漀氀攀挀甀氀愀爀 愀猀瀀攀挀琀猀 漀昀 琀栀攀 最攀渀甀猀Ⰰ 氀攀搀 琀漀 琀栀攀 搀攀挀漀搀椀渀最 漀昀 琀栀爀攀攀 㰀椀㸀倀愀爀愀挀漀挀挀椀搀椀漀椀搀攀猀㰀⼀椀㸀 最攀渀漀洀攀猀Ⰰ 琀眀漀 漀昀 琀栀攀洀 ⠀倀戀　㌀ 愀渀搀 倀戀㄀㠀⤀ 㰀椀㸀倀⸀ 戀爀愀猀椀氀椀攀渀猀椀猀㰀⼀椀㸀 愀渀搀 漀渀攀 ⠀倀戀　㄀⤀ 㰀椀㸀倀⸀ 氀甀琀稀椀椀㰀⼀椀㸀⸀    In this conference, we intend to discuss some of the most relevant aspects of recent biological research on the genus Paracoccidioides, and provide ideas for future lines of investigation. ਀㰀⼀昀漀渀琀㸀㰀⼀瀀㸀㰀戀爀㸀㰀戀㸀䬀攀礀眀漀爀搀㨀 㰀⼀戀㸀☀渀戀猀瀀㬀倀愀爀愀挀漀挀挀椀搀椀漀椀搀攀猀Ⰰ 戀椀漀氀漀最礀Ⰰ 洀漀氀攀挀甀氀愀爀Ⰰ 猀瀀攀挀椀愀琀椀漀渀Ⰰ 戀椀漀挀栀攀洀椀猀琀爀礀㰀⼀琀搀㸀㰀⼀琀爀㸀㰀⼀琀愀戀氀攀㸀㰀⼀琀爀㸀㰀⼀琀搀㸀㰀⼀琀愀戀氀攀㸀㰀⼀戀漀搀礀㸀㰀⼀栀琀洀氀㸀