XI International Meeting on Paracoccidioidomycosis

XI International Meeting on Paracoccidioidomycosis

Resume:137-6

Poster (Painel)

137-6	Prevalence of blood group antigens in paracoccidioidomycosis-patients. Preliminary results.
Authors:	Jessica Enéas Fulfaro (FMB - UNESP - FACULDADE DE MEDICINA DE BOTUCATU - UNESP) ; Elenice Deffune (HB - HEMOCENTRO DE BOTUCATUFMB - UNESP - FACULDADE DE MEDICINA DE BOTUCATU - UNESP) ; Rinaldo Poncio Mendes (FMB - UNESP - FACULDADE DE MEDICINA DE BOTUCATU - UNESP)

Abstract

Introduction. Paracoccidioidomycosis (PCM), systemic mycosis with antigen-dependent immunosupression, has not been evaluated as to genetic factors of susceptibility and resistance. Objectives. This study investigated the prevalence of different red blood cells surface antigens in PCM-patients as to clinical forms. Patients and Methods. A total of 105 patients with PCM confirmed by the identification of typical Paracoccidioides brasiliensis yeast forms in different clinical materials and/or anti-P. brasiliensis antibodies demonstrated by the double agar gel immunodiffusion test, in any phase of the disease, were enrolled in this study. Co-morbidities, except alcohol intake and smoking habit, were exclusion criteria. Clinical forms and severity were classified as to Mendes et al. (1994). Three groups were constituted: G1- 21 patients / acute/subacute form (AF); G2- 84 patients / chronic form (CF); G3 - control group - 157 donors from Botucatu Blood Center . ABO, MNS, Rh, Kell, Lewis, Duffy and Kidd were the blood group systems evaluated by using the ID-Micro-Typing SystemTM (ID-MTS) Gel TestTM. Frequencies were compared by Fisher’s exact test or chi-square test; significance was set up at p ≤ 0.05. Results. The frequencies of the antigens in each different blood group systems will be presented in percentage in PCM-patients as a whole (G1+G2), in G1, G2 and G3: a) ABO system: O (52.4, 57.1, 51.2, 49.0), A (35.0, 38.1, 34.1, 36.5), B (11.7, 4.8, 13.4, 10.9), AB (1.0, 0.0, 1.2, 3.6); b) Rh system: D (89.3, 90.5, 89.0, 82.2); C (66.3, 57.1, 68.7, 63.7); c (76.2, 81.0, 75.0, 73.9); E (31.4., 42.9, 28.6, 30.0); e (96.2, 85.7, 98.8, 94.3); c) Duffy system: Fya (64.0, 50.0, 64.6, 64.3); Fyb (41.3, 26.7, 45.0, 71.3); d) Kidd system: Jka (49.3, 53.8, 48.2, 70.7); Jkb (66.7, 50.0, 68.8, 70.0); e) MNS system: M (75.0, 80.0, 73.8, 76.4); N (57.7, 53.8, 58.5, 68.8); S (43.6, 35.3, 45.5, 47.2); s (92.3, 95.0, 91.7, 94.9); f) Lewis system: Lea (8.0, 5.0, 8.8, 15.3); Leb (37.2, 35.7, 37.5, 66.3); g) Kell system: K (8.7, 10.0, 8.4, 18.5). A lower frequency of Fyb, K and Leb was observed in PCM-p [p < 0.05]. As to clinical form, “e” antigen (Rh system) showed lower frequency in the AF (85.7%) than in the CF (98.8%) [p = 0.02]. Conclusion. We are now studying if these findings could be a risk factor for PCM or if they influence its clinical expression.

Keyword: paracoccidioidomycosis, blood group antigens, phenotyping

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