XI International Meeting on Paracoccidioidomycosis

XI International Meeting on Paracoccidioidomycosis

Resume:137-3

Poster (Painel)

137-3	Prevalence of blood group antigens in paracoccidioidomycosis-patients. Preliminary results.
Authors:	Jessica Enéas Fulfaro (FMB - UNESP - Faculdade de Medicina - UNESP) ; Elenice Deffune (FMB - UNESP - Hemocentro de Botucatu - FMB - UNESP) ; Tatiane Fernanda Sylvestre (FMB - UNESP - Faculdade de Medicina - UNESP) ; Rinaldo Poncio Mendes (FMB - UNESP - Faculdade de Medicina - UNESP)

Abstract

Introduction. Paracoccidioidomycosis (PCM), systemic mycosis with antigen-dependent immunosupression, has not been evaluated as to genetic factors of susceptibility and resistance. Objectives. This study investigated the prevalence of different red blood cells surface antigens in PCM-patients as to clinical forms. Patients and Methods. A total of 105 patients with PCM confirmed by the identification of typical Paracoccidioides brasiliensis yeast forms in different clinical materials and/or anti-P. brasiliensis antibodies demonstrated by the double agar gel immunodiffusion test, in any phase of the disease, were enrolled in this study. Co-morbidities, except alcohol intake and smoking habit, were exclusion criteria. Clinical forms and severity were classified as to Mendes et al. (1994). Two groups were constituted: G1- 21 patients with the acute/subacute form; G2- 84 patients with the chronic form. ABO, MNS, Rh, Kell, Lewis, Duffy and Kidd were the blood group systems evaluated by using the ID-Micro-Typing SystemTM (ID-MTS) Gel TestTM. Frequencies were compared by Fisher’s exact test or chi-square test; significance was set up at p ≤ 0.05. Results. The frequencies of the antigens in each different blood group systems will be presented in percentage in PCM-patients as a whole (G1+G2), and in G1 and G2: a) ABO system: O (52.4, 57.1, 51.2), A (35.0, 38.1, 34.1), B (11.7, 4.8, 13.4), AB (1.0, 0.0, 1.2); b) Rh system: D (89.3, 90.5, 89.0); C (66.3, 57.1, 68.7); c (76.2, 81.0, 75.0); E (31.1, 42.9, 28.6); e (96.2, 85.7, 98.8); c) Duffy system: Fya (64.0, 50.0, 64.6); Fyb (41.3, 26.7, 45.0); d) Kidd system: Jka (49.3, 53.8, 48.2); Jkb (66.7, 50.0, 68.8); e) MNS system: M (75.0, 80.0, 73.8); N (57.7, 53.8, 58.5); S (43.6, 35.3, 45.5); s (92.3, 95.0, 91.7); f) Lewis system: Lea (8.0, 5.0, 8.8); Leb (37.2, 35.7, 37.5); g) Kell system: K (8.7, 10.0, 8.4). The only difference observed as to clinical form was the “e” antigen (Rh system) frequency, with 85.7% in acute/subacute form and 98.8% in chronic form [p = 0.02]. Conclusion. The frequency of the majority red blood cells surface antigens did not differ as to clinical form, except the higher prevalence of the “e” antigen of Rh system in the chronic form. The study of the frequencies according to severity of the disease and the comparison with regional population are in progress. ਀

Keyword: blood group, surface antigens, paracoccidioidomycosis

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