XI International Meeting on Paracoccidioidomycosis
Resume:111-1


Investigação
111-1Lipid mediators of the immune response to fungi
Authors:Alexandra Ivo de Medeiros (FCFAR-UNESP - Faculdade de Ciências Farmacêuticas)

Abstract

Lipid mediators are a prominent class of molecules derived from arachidonic acid (AA) metabolism involved in the antimicrobial defense of the lung. In general, the lipid mediators leukotriene (LT) B4, cysteinyl-LTs (LTC4, LTD4 and LTE4) and prostaglandin E2 (PGE2) have opposite effects on pulmonary defense mechanisms. ਀圀攀 栀愀瘀攀 爀攀瀀漀爀琀攀搀 瀀爀攀瘀椀漀甀猀氀礀Ⰰ 爀攀最愀爀搀椀渀最 琀栀攀 瀀爀椀洀愀爀礀 椀洀洀甀渀攀 爀攀猀瀀漀渀猀攀 琀漀 㰀椀㸀䠀椀猀琀漀瀀氀愀猀洀愀 挀愀瀀猀甀氀愀琀甀洀㰀⼀椀㸀Ⰰ 琀栀愀琀 琀栀攀 椀渀栀椀戀椀琀椀漀渀 漀昀 攀渀搀漀最攀渀漀甀猀 䰀吀猀 爀攀猀甀氀琀攀搀 椀渀 ㄀  ─ 洀漀爀琀愀氀椀琀礀 椀渀 猀甀戀氀攀琀栀愀氀氀礀 㰀椀㸀䠀⸀ 挀愀瀀猀甀氀愀琀甀洀㰀⼀椀㸀ⴀ椀渀昀攀挀琀攀搀 洀椀挀攀Ⰰ 栀椀最栀攀爀 渀甀洀戀攀爀猀 漀昀 氀甀渀最 愀渀搀 猀瀀氀攀攀渀 䌀漀氀漀渀礀 䘀漀爀洀椀渀最 唀渀椀琀 ⠀䌀䘀唀⤀Ⰰ 椀洀瀀愀椀爀攀搀 一椀琀爀椀挀 伀砀椀搀攀 ⠀一伀⤀ 瀀爀漀搀甀挀琀椀漀渀 愀渀搀 椀渀栀椀戀椀琀攀搀 吀栀㄀ⴀ挀礀琀漀欀椀渀攀 攀砀瀀爀攀猀猀椀漀渀⸀ 䠀椀最栀攀爀 猀甀猀挀攀瀀琀椀戀椀氀椀琀礀 椀渀 㔀ⴀ䰀伀ⴀ⼀ⴀ 洀椀挀攀 挀漀爀爀攀氀愀琀攀猀 眀椀琀栀 搀攀挀爀攀愀猀攀搀 瀀栀愀最漀挀礀琀椀挀 挀愀瀀愀挀椀琀礀 漀昀 䤀最䜀ⴀ漀瀀猀漀渀椀稀攀搀 䠀挀 戀礀 洀愀挀爀漀瀀栀愀最攀猀 眀栀攀渀 挀漀洀瀀愀爀攀搀 琀漀 圀吀⸀ 䠀漀眀攀瘀攀爀Ⰰ 攀砀漀最攀渀漀甀猀 䰀吀䈀㐀 愀渀搀 䰀吀䌀㐀 爀攀猀琀漀爀攀搀 瀀栀愀最漀挀礀琀漀猀椀猀 搀攀昀椀挀椀攀渀挀礀 椀渀 洀愀挀爀漀瀀栀愀最攀猀⸀ 伀甀爀 爀攀猀甀氀琀猀 搀攀洀漀渀猀琀爀愀琀攀 琀栀愀琀 䰀吀猀 愀爀攀 愀挀琀甀愀氀氀礀 爀攀焀甀椀爀攀搀 琀漀 挀漀渀琀爀漀氀 挀栀爀漀渀椀挀 昀甀渀最愀氀 椀渀昀攀挀琀椀漀渀 椀渀 戀漀琀栀 椀渀渀愀琀攀 愀渀搀 愀搀愀瀀琀椀瘀攀 椀渀 瀀爀椀洀愀爀礀 椀洀洀甀渀攀 爀攀猀瀀漀渀猀攀猀 椀渀 栀椀猀琀漀瀀氀愀猀洀漀猀椀猀⸀ 䴀漀爀攀漀瘀攀爀Ⰰ 椀渀 猀甀戀猀攀焀甀攀渀琀 猀琀甀搀椀攀猀 眀攀 栀愀瘀攀 搀漀挀甀洀攀渀琀攀搀 愀 瀀爀漀琀攀挀琀椀瘀攀 昀甀渀挀琀椀漀渀 漀昀 䰀吀猀 椀渀 琀栀攀 猀攀挀漀渀搀愀爀礀 椀洀洀甀渀攀 爀攀猀瀀漀渀猀攀 愀最愀椀渀猀琀 㰀椀㸀䠀⸀ 挀愀瀀猀甀氀愀琀甀洀㰀⼀椀㸀⸀ 䤀渀 琀栀攀 瀀爀攀猀攀渀琀 猀琀甀搀礀Ⰰ 眀攀 搀攀洀漀渀猀琀爀愀琀攀 琀栀愀琀 琀栀攀 瀀爀漀琀攀挀琀椀漀渀 漀昀 圀吀 洀椀挀攀 椀洀洀甀渀椀稀攀搀 眀椀琀栀 䌀攀氀氀ⴀ䘀爀攀攀 䄀渀琀椀最攀渀猀 ⠀䌀䘀䄀最猀⤀ 愀最愀椀渀猀琀 䠀⸀ 挀愀瀀猀甀氀愀琀甀洀 椀渀昀攀挀琀椀漀渀 椀猀 愀猀猀漀挀椀愀琀攀搀 眀椀琀栀 琀栀攀 椀渀挀爀攀愀猀攀 漀昀 䰀吀䈀㐀Ⰰ 一伀 愀渀搀 䤀䘀一ⴀ最愀洀洀愀 瀀爀漀搀甀挀琀椀漀渀Ⰰ 愀渀搀 琀栀攀 爀攀挀爀甀椀琀洀攀渀琀 漀昀 洀攀洀漀爀礀 吀 挀攀氀氀猀⸀ 䠀漀眀攀瘀攀爀Ⰰ 琀栀攀 搀攀昀椀挀椀攀渀挀礀 漀昀 䰀吀 瀀爀漀搀甀挀琀椀漀渀 椀渀 㔀ⴀ䰀伀 䬀伀 洀椀挀攀 椀洀瀀愀椀爀攀搀 琀栀攀 瀀爀漀琀攀挀琀椀漀渀 椀渀搀甀挀攀搀 戀礀 䌀䘀䄀最猀⸀ 吀栀椀猀 攀昀昀攀挀琀 椀猀 愀猀猀漀挀椀愀琀攀搀 眀椀琀栀 琀栀攀 椀渀栀椀戀椀琀椀漀渀 漀昀 爀攀挀爀甀椀琀洀攀渀琀 愀渀搀⼀漀爀 愀挀琀椀瘀愀琀椀漀渀 漀昀 攀昀昀攀挀琀漀爀 洀攀洀漀爀礀 吀 挀攀氀氀猀 搀甀爀椀渀最 㰀椀㸀䠀⸀ 挀愀瀀猀甀氀愀琀甀洀㰀⼀椀㸀 椀渀昀攀挀琀椀漀渀Ⰰ 爀攀猀甀氀琀椀渀最 椀渀 洀漀爀琀愀氀椀琀礀 漀昀 椀洀洀甀渀椀稀攀搀 洀椀挀攀 愀渀搀 椀渀挀爀攀愀猀攀搀 䌀䘀唀 椀渀 琀栀攀 氀甀渀最 愀渀搀 猀瀀氀攀攀渀⸀ Our studies have contributed to demonstrating the important role for LTs on both sides of host defense against to fungi.਀㰀⼀昀漀渀琀㸀㰀⼀瀀㸀㰀戀爀㸀㰀戀㸀䬀攀礀眀漀爀搀㨀 㰀⼀戀㸀☀渀戀猀瀀㬀䰀椀瀀椀搀 䴀攀搀椀愀琀漀爀猀Ⰰ 䠀椀猀琀漀瀀氀愀猀洀愀 挀愀瀀猀甀氀愀琀甀洀Ⰰ 䠀漀猀琀 搀攀昀攀渀猀攀Ⰰ 䌀礀琀漀欀椀渀攀猀Ⰰ 䰀攀甀欀漀琀爀椀攀渀攀猀㰀⼀琀搀㸀㰀⼀琀爀㸀㰀⼀琀愀戀氀攀㸀㰀⼀琀爀㸀㰀⼀琀搀㸀㰀⼀琀愀戀氀攀㸀㰀⼀戀漀搀礀㸀㰀⼀栀琀洀氀㸀