XI International Meeting on Paracoccidioidomycosis

XI International Meeting on Paracoccidioidomycosis

Resume:45-7

Poster (Painel)

45-7	GEOGRAPHICAL MAPPING OF PARACOCCIDIOIDOMYCOSIS IN SÃO PAULO STATE, BY SEROLOGICAL ANALYSIS PERFORMED AT INSTITUTO ADOLFO LUTZ.
Authors:	Camila Mika Kamikawa (IAL - Instituto Adolfo Lutz de Sao Paulo) ; Valdelene Sayuri Kohara (IAL - Instituto Adolfo Lutz de Sao Paulo) ; Angela Noronha Passos (IAL - Instituto Adolfo Lutz de Sao PauloPG-CCD-SES-SP - Programa de Pos Graduacao em Ciencias (CCD-SES-SP)) ; Adriana Pardini Vicentini (IAL - Instituto Adolfo Lutz de Sao Paulo)

Abstract

Paracoccidioidomycosis (PCM) is a systemic mycosis caused by Paracoccidioides brasiliensis. It is known that PCM is highly endemic in São Paulo State, but there are many difficulties in establishing the true incidence of it, since it is not compulsory notification. We evaluated the geographic distribution of PCM in Sao Paulo State through a retrospective study of secondary data on the serological analysis, carried out by double immunodiffusion assay (DI) of patients with clinical suspicion of PCM, sent to the Laboratorio de Imunodiagnostico das Micoses do Instituto Adolfo Lutz de São Paulo (LIM/IAL/SP), from january 1999 to may 2010. The LIM/IAL/SP has registered in its database, 10,176 patients with clinical suspicion of PCM, which were classified according to the Departamento Regional de Saude (DRS). Analyzing patients with anti-P. brasiliensis antibodies we found that 88.9% reagent samples were males and 11.1% females, showing masculinity rate of 8:1; the age distributions ranged between 41 to 60 years for both sexes, and 17 (1.0%) were aged 0-10 years. From 239 municipalities that sent samples for analysis 60% had at least one patient with anti-P. brasiliensis antibodies detected. Among the DRSs, DRS-14 (São João da Boa Vista) with 85%, DRS-10 (Piracicaba) with 75%, DRS-16 (Sorocaba) with 73%, DRS-7 (Campinas) 72% and DRS-1 (Capital and Greater Sao Paulo) with 62% were the municipalities that had more patients with serologically reactivity. São Paulo State has an area of 248,209.4 km², stretching from the coastline to inward. The climate is tropical and sub-tropical with annual temperatures between 18 and 24°C, high rainfall, ranging from 900 to 1800 mm, with rainy summers, mild winters. It also highlights the existence of large areas composed of acid soils. It is one of the Brazil units that contributed with the most to national agricultural production and, separately, the largest producer of orange juice and, the ninth largest producer of soy and sugar cane and the fourth largest coffee producer. In cattle raising, the state also stands out as being responsible for producing of broilers (16%), cattles (9%) and pigs (7%) in the country. We conclude that the climatic characteristics associated with soil type and the primary activities developed, contribute to the endemic potential of PCM in Sao Paulo State.

Keyword: Epidemiology, Immunodiagnosis, Paracoccidioidomycosis, Paracoccidioides brasiliensis

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