ÿþ<HTML><HEAD><TITLE>XI International Meeting on Paracoccidioidomycosis</TITLE><link rel=STYLESHEET type=text/css href=css.css></HEAD><BODY aLink=#ff0000 bgColor=#FFFFFF leftMargin=0 link=#000000 text=#000000 topMargin=0 vLink=#000000 marginheight=0 marginwidth=0><table align=center width=700 cellpadding=0 cellspacing=0><tr><td align=left bgcolor=#cccccc valign=top width=550><font face=arial size=2><strong><font face=Verdana, Arial, Helvetica, sans-serif size=3><font size=1>XI International Meeting on Paracoccidioidomycosis</font></font></strong><font face=Verdana size=1><b><br></b></font><font face=Verdana, Arial,Helvetica, sans-serif size=1><strong> </strong></font></font></td><td align=right bgcolor=#cccccc valign=top width=150><font face=arial size=2><strong><font face=Verdana, Arial, Helvetica, sans-serif size=1><font size=1>Resume:45-3</font></em></font></strong></font></td></tr><tr><td colspan=2><br><br><table align=center width=700><tr><td><b>Poster (Painel)</b><br><table width="100%"><tr><td width="60">45-3</td><td><b>PARACOCCIDIOIDOMYCOSIS IN SOROCABA CITY-SAO PAULO,BRAZIL.</b></td></tr><tr><td valign=top>Authors:</td><td><u>Camila Mika Kamikawa </u> (IAL - Instituto Adolfo Lutz) ; Valdelene Sayuri Kohara (IAL - Instituto Adolfo Lutz) ; Angela Noronha Passos (IAL - Instituto Adolfo LutzPG-CCD-SES-SP - Programa de Pos Graduacao em Ciencias) ; Adriana Pardini Vicentini (IAL - Instituto Adolfo Lutz) </td></tr></table><p align=justify><b><font size=2>Abstract</font></b><p align=justify class=tres><font size=2>Considered the eighth leading cause of mortality among chronic, infectious and parasitic diseases in Brazil, paracoccidioidomycosis (PCM) is a systemic mycosis caused by <i>Paracoccidioides brasiliensis</i>. Serological diagnosis, made by double immunodiffusion (DI) assay, is important because of its low cost, easy to perform and less time to obtain results. Furthermore, it assumes great importance because it allows monitoring of the disease as well as by offering subsidies for seroepidemiological surveys. We evaluate the percentage of reactivity of PCM in Sorocaba by analysis of database obtained from the Laboratório de Imunodiagnóstico das Micoses, Instituto Adolfo Lutz, São Paulo (IAL-SP), from 1999 to September 2010. Informations such as age, sex, origin of medical application, serological results were evaluated. Of the 639 patients, 17.7% were seropositive, 82% are male and 18% of women (approximate ratio 8:2). The age of the individuals ranged from 0 to 94 years. We observed that 72% of male reagents patients range from 41 to 60 years. Among women reagents, 35% were aged 41 to 50 and 20% between 1-10 years at time of request for examination. Among patient s reagents, 56% had only one sample sent to the IAL-SP during the study period and 156 patients were monitored serologically. Of these, 80% were monitored for less than one year. We observed that 13 patients had profile changes in response to <i>Paracoccidioides brasiliensis</i>(reagent for non-reactive). Seventy-one percent of patients showed no serological follow-up in the IAL-SP from 2005. The analysis allows us to state that patients living in Sorocaba have significant serologic reactivity to <i>Paracoccidioides brasiliensis</i>, suggesting the disease endemic in the region. The relationship between males and females approximately 8:2 corroborate the literature data. The ages of patient s reagents suggests that the chronic form of PCM is the predominant clinical manifestations among patients. However, among female patients, the acute form of disease was significant. Observing the serological monitoring of these patients, we feel the need for professionals to follow the guidelines established by the Brazilian Consensus on Paracoccidioidomycosis and in the Manual for the Surveillance of Paracoccidioidomycosis of the State of Sao Paulo to follow-up serologic, clinical and therapeutic. </font></p><br><b>Keyword: </b>&nbsp;Database, Epidemiologycal analysis, Immunodiffusion assay, Paracoccidioidomycosis, Sorocaba</td></tr></table></tr></td></table></body></html>