XI International Meeting on Paracoccidioidomycosis

XI International Meeting on Paracoccidioidomycosis

Resume:24-2

Poster (Painel)

24-2

Paracoccidioidic infection in children of rural area in Mato Grosso do Sul, Brazil

Authors:

Ana Paula da Costa Marques (UFMS - Universidade Federal do Mato Grosso do Sul) ; Sandra Maria do Valle Leone de Oliveira (UFMS - Universidade Federal do Mato Grosso do Sul) ; Grazielli Rezende (UFMS - Universidade Federal do Mato Grosso do Sul) ; Dayane Alves Melo (UFMS - Universidade Federal do Mato Grosso do Sul) ; Sonia Maria Fernandes (UFMS - Universidade Federal do Mato Grosso do Sul) ; Monica Meinert (UNIDERP - Universidade Anhanguera-Uniderp) ; Janaina Michelle de Oliveira (UFMS - Universidade Federal do Mato Grosso do Sul) ; Maria da Glã³ria Bonecini de Almeida (FIOCRUZ - FundaÃ§Ã£o Oswaldo Cruz) ; Zoilo Pires de Camargo (UNIFESP-EPM - Universidade Federal de SÃ£o Paulo) ; Anamaria Melo Miranda Paniago (UFMS - Universidade Federal do Mato Grosso do Sul)

Abstract

Paracoccidioidomycosis is the most prevalent chronic systemic mycosis in Latin America caused by dimorphic fungus Paracoccidioides brasiliensis. Epidemiological surveys suggest that about 50% of inhabitants of endemic areas have been infected by this fungus. The infection is primarily acquired in the first two decades of life with a peak incidence between 10 and 20 years old. Several authors have called attention to the importance of epidemiologically value children presenting the acute phase of disease, especially because this children in Latin America are involved in various agricultural activities since the early years of life, so the goal of our study was to determine the prevalence of paracoccidioidic infection among children living in rural settlements in the State of Mato Grosso do Sul. Intradermal tests were performed with gp-43 in 156 children between 2-18 years old by injection 0.1 mL of antigen in the left forearm. Tests were read 48 hours after injection and a 5 mm or greater induration was considered positive. The prevalence of paracoccidioidic infection in the study population was 21.2% and 60.6% were male. Stratified by age, among children 2-6 years old 12% were positive to the test, those with 7-12 years old, the prevalence was 16.4% and from 13-18 years old 29.7%. Much of children reported even without performing activities in the fields accompanied their parents when they were not in school. The results of this study suggest the presence of the fungus Paracoccidioides brasiliensis in this region. Furthermore, it demonstrates the early exposure of children to the risk factors that favor the fungus infection, indicating the importance of establishing mechanisms for early diagnosis and illness insurance for which treatment can be instituted quickly and effectively.

Keyword: Children, Gp43, Paracoccidioides brasiliensis, Paracoccidiodic infection, Rural Settlements

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