XI International Meeting on Paracoccidioidomycosis

XI International Meeting on Paracoccidioidomycosis

Resume:24-1

Poster (Painel)

24-1

Paracoccidioides brasiliensis infection in the population of rural settlements in the Estate of Mato Grosso do Sul, Brazil

Authors:

Ana Paula da Costa Marques (UFMS - Universidade Federal do Mato Grosso do Sul) ; Sandra Maria do Valle Leone de Oliveira (UFMS - Universidade Federal do Mato Grosso do Sul) ; Grazielli Rezende (UFMS - Universidade Federal do Mato Grosso do Sul) ; Dayane Alves Melo (UFMS - Universidade Federal do Mato Grosso do Sul) ; Sonia Maria Fernandes (UFMS - Universidade Federal do Mato Grosso do Sul) ; Monica Meinert (UNIDERP - Universidade Anhanguera-Uniderp) ; Janaina Michelle de Oliveira (UFMS - Universidade Federal do Mato Grosso do Sul) ; Maria da Glã³ria Bonecini de Almeida (FIOCRUZ - FundaÃ§Ã£o Oswaldo Cruz) ; Zoilo Pires de Camargo (UNIFESP-EPM - Universidade Federal de SÃ£o Paulo) ; Anamaria Melo Miranda Paniago (UFMS - Universidade Federal do Mato Grosso do Sul)

Abstract

The fungus Paracoccidioides brasiliensis causes paracoccidioidomycosis (PCM), the prevalent chronic systemic mycosis in many Latin American countries (Brazil, Venezuela, Colombia, Ecuador and Argentina). The PCM represents a serious public health problem because of its potential crippling and premature death mainly to specific social segments, such as rural workers. Studies on the epidemiology of PCM are based on surveys conducted with intradermal tests, and the paracoccidioidin used in most cases. However, the most antigenic component of P. brasiliensis is a secreted glycoprotein of 43κ Da (gp-43). There are no studies using gp-43 in skin tests among population of rural settlements in Brazil, so the goal was to determine the prevalence of infection with P. brasiliensis using gp-43 between the inhabitants of settlements of Mato Grosso do Sul (MS). Intradermal tests were performed in 695 individuals by injection 0.1mL of gp-43 in the left forearm. Tests were read 48h after injection and a 5mm or greater induration was considered positive. The infection rate was 45.8% and 48.8% of men and 41.9% of women were tested positive. There was no signicant difference between the sexes. The average age of infected individuals was 45.8 years old. The prevalence increased significantly with age. Among the risk factors for infection we observed a statistically significant association with agricultural labor. Individuals who reported having hunted armadillo 50.8% were positive skin test and no statistical difference was observed. The results of this study demonstrate the importance of infection with P. brasiliensis in rural settlements of MS. The age and farm work are associated with infection. Furthermore, smoking and alcohol found in the study population are potential risk factors.

Keyword: Gp43, Mato Grosso do Sul, Paracoccidioides brasiliensis, Paracoccidioidomicose, Rural Settlements

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