XI International Meeting on Paracoccidioidomycosis

XI International Meeting on Paracoccidioidomycosis

Resume:43-2

Poster (Painel)

43-2

Evaluation of laboratory measurements in untreated paracoccidioidomycosis-patients. ਀

Authors:

Tatiane Fernanda Sylvestre (FMB - UNESP - Faculdade de Medicina de Botucatu) ; Adriele Dandara Levorato (FMB - UNESP - Faculdade de Medicina de Botucatu) ; Daniela Vanessa Moris (FMB - UNESP - Faculdade de Medicina de Botucatu) ; Priscila Zacarias Azevedo (FMB - UNESP - Faculdade de Medicina de Botucatu) ; Ricardo de Souza Cavalcante (FMB - UNESP - Faculdade de Medicina de Botucatu) ; Lídia Raquel Carvalho (IBB - UNESP - Instituto de Biociências) ; Rinaldo Poncio Mendes (FMB - UNESP - Faculdade de Medicina de Botucatu)

Abstract

Introduction. The clinical evaluation of Paracoccidioidomycosis-patients (PCM-p) is frequently completed by laboratory tests. The aims of this study are to evaluate biochemical and hematological variables in untreated patients. Patients and Methods. We studied 83 PCM-p confirmed by identification of the etiological agent or detection of serum antibodies by double agar gel immunodiffusion test, clinically classified according to Mendes et al.(1994): 29 presented the acute/subacute severe form (G1), 35 the chronic moderate form (G2) and 19 the chronic severe form (G3). Biochemical and hematological exams were performed in routine clinical laboratories at the University Hospital – UNESP. Comparison of medians were carried out by Kruskal-Wallis test and significance was set up at p<0.05. Results. Serum total cholesterol presented low levels (G1(G2=G3)]. Calcium, phosphorus, glucose (fasted), aminotransferases, uric acid, tryglicerides and &gamma-glutamil transferase were always normal. Hemoglobin (g%) [G1=11.1; G2=15.1; G3=14.6] and hematocrit (%) [G1=34.5; G2=44.2; G3=43.4] showed low values only in G1 [G1<(G2=G3)]; eosinophils count (no./mm3) [G1=616; G2=430; G3=256] was increased only in G1 [G1>(G2=G3)]; platelet count (no./mm3) [G1=380,500; G2=311,000; G3=358,000] was normal in all the groups, but with difference among them [G2<(G1=G3)]; neutrophils [G1=5,519; G2=6,360; G3=6,6,832], total lymphocytes [G1=1,821.5; G2=2,121; G3=2,125] and monocytes [G1=480; G2=485; G3=820] count were normal (G1=G2=G3). Erythrocyte sedimentation rate (mm/1st hour) [G1=43; G2=29; G3=30] was always increased [G1>(G2=G3)]. Conclusions. The biochemical alterations caused by P. brasiliensis demonstrates its intense metabolic interference and the hematological alterations caused by P. brasiliensis suggest careful follow-up of PCM-p, with routine evaluation of the hemogram and erythrocyte sedimentation rate.

Keyword: Biochemical, Hematological, Paracoccidioidomycosis, Untreated patients, Variables

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